Polypharmacy is a growing concern that requires a multi-faceted approach for effective management. The risks of polypharmacy are significant, but with the right strategies in place, we can mitigate those risks and improve patient outcomes in older adults. This conference will support you to understand the complex issues around problematic polypharmacy and stopping inappropriate medicines safely in older adults. The conference will discuss current issues and trends, support clinicians to identify problematic polypharmacy, develop your skills in leading effective shared decision making structured medication reviews and focus on difficult issues such as discontinuing mental health medications, understand interactions with herbal and dietary supplements and explore strategies for discontinuation syndromes, adverse effects and tapering.